TOLL-LIKE RECEPTOR AGONISTS SYNERGIZE WITH CD40L TO INDUCE EITHER PROLIFERATION OR PLASMA CELL DIFFERENTIATION OF MOUSE B CELLS.

Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells.

In a classical dogma, pathogens are sensed (via recognition of Pathogen Associated Molecular Patterns (PAMPs)) by innate immune cells that in turn activate adaptive immune cells.However, recent data showed that TLRs (Toll Like Receptors), the most characterized class of Pattern Recognition Receptors, are also expressed by adaptive immune B cells.B

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Larvae of the Clothing Moth Tineola bisselliella Maintain Gut Bacteria that Secrete Enzyme Cocktails to Facilitate the Digestion of Keratin

The evolutionary success of insects is promoted by their association with beneficial microbes that enable the utilization of unusual Motor diets.The synanthropic clothing moth Tineola bisselliella provides an intriguing example of this phenomenon.The caterpillars of this species have adapted to feed on keratin-rich diets such as feathers and wool,

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